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Volume 1, # 1 - May, 1995

Table of Contents

STATE-OF-THE-ART MANAGEMENT OF CANCER
CANCERS OF THE DIGESTIVE SYSTEM - PART I
Epidemiology, Etiology, Pathogenesis and Staging by Type of Cancer 2
  Esophageal Cancer 2
  Stomach Cancer 3
  Liver/Billiary Cancer 4
  Pancreatic Cancer 6
  Gallbladder Cancer 6
  Colorectal Cancer 7
  Cancer of the Small Intestine 10
  Anal Cancer 12
MEETING COVERAGE
5TH INTERNATIONAL CONGRESS ON ANTI-CANCER CHEMOTHERAPY (ICACC)
January 31 TO Februrary 3, 1995 - Paris, France
New Chemotherapeutics Approaches in the Treatment of Gastrointestinal Cancer 13
  Esophageal Cancer 13
  Stomach Cancer 13
  Pancreatic Cancer 14
  Colorectal Cancer 15
Platinum-Based Drugs 16
  Cisplating and Carboplatin 16
  New Platinum Agents 16
    Oxaliplatin 17
    Tetraplatin 17
    JM-216 17
  Overcoming Drug Resistance 18
    Modifications of metallothionein levels 18
    Exploitation of metabolic defects of tumors 18
    Modulation of glutathione 18
    Glutathione S-transferase (GST) isoenzyme inhibitors 18
  Improving Drug Delivery 20
    Matrix Pharmaceutical 20
    Alkermes 21
  Reducing Side Effects 21
    Amifostine 21
    Tirapazamine 21
MECHANISMS IN MALIGNANCY
APOPTOSIS
Death by apoptosis 2
  In the constant shadow of death 22
  How cells die 22
  Anoikis leads to death 22
Apoptosis and malignancy 22
  Apoptosis deregulation may participate in oncogenesis and induces drug resistance 22
  Cancer - a paradigm for apoptosis-based interventions 23
  Apoptosis treshold of cells may determine toxicity 23
  Molecular regulators of apoptosis 23
    bcl-2 23
    c-abl 23
    Bax 23
    Bak 24
    p53 24
    c-myc 24
    Interleukin-1B converting enzyme 24
    Hormones 24
    Cytokines 25
Paradox 25
  Dominant oncogenes inhibit and promote apoptosis 25
  The ultimate apoptosis signals may reside in the cytoplasm 25
  Apoptosis may help malignant cells avoid host immune mechanisms 25
  Anticancer drugs may induce mutations in key apoptosis regulating genes 25
  Apoptosis may play a role in spontaneous remissions 25
Apoptosis in anticancer drug development 25
  Gene transfer 26
    Canji 26
    Introgen Therapeutics 26
    Ingenex 26
  Oligonucleotide-based strategies 26
    Genta 26
    Lynx 26
  Small molecules 27
    Apoptosis Technology 27
    Mitotix 27
    Onyx Pharmaceuticals 27
    IDUN 28
  Nuclear Matrix Proteins 28
    Matritech 28
  Telomerase Inhibitors 28
    Geron 28
  Angiogenesis Inhibitors 28
    Ixsys 28
  Photodynamic Therapy (PDT) 28
  Enediynes 28
  Other apoptosis-based anticancer drug development 28
    LXR Biotechnology 28
    Ligand Pharmaceuticals 28
    Ansan 28
    Cell Pathways 28
    Receptagen 28

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