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Volume 1, # 5 - September, 1995

Table of Contents

STATE-OF-THE-ART MANAGEMENT OF CANCER
MALIGNANT MELANOMA
Etiology and Risk Factors 117
Pathogenesis, Classification, Staging and Prognosis 118
Epidemiology 119
Diagnosis 122
Current Disease Management Approaches 123
  Surgery 124
  Chemotherapy 125
    Dacarbazine 125
    Fotemustine 125
    Vindesine 125
    Interferon-alpha 2b 126
    Interferon-alpha 2a 126
  Sequential Chemoimmunotherapy 126
MEETING COVERAGE
19TH INTERNATIONAL CONGRESS OF CHEMOTHERAPY
Montreal, Quebec, Canada - July 16-21, 1995
New Treatment Approaches for Infections In Neutropenic Patients 127
  Piperacillin/Tazobactam 127
  Recombinant Granulocyte-Colony Stimulating Factor Combination Therapy 128
  Meropenem 128
  Pefloxacin with Teicoplanin 128
  Ciprofloxacin 128
  Fluconazole 128
MECHANISMS IN MALIGNANCY
DRUG RESISTANCE IN CANCER - PART III
Novel Agents in Development to Overcoming P-Glycoprotein-Mediated Resistance 129
  Novel Drugs Being Evaluated in P-gp MDR 129
    Byk Gulden 129
    Cell Therapeutics 129
    CytRx 129
    Knoll Pharmaceuticals 129
    Vertex Pharmaceuticals 130
    Xenova 130
    Oligonucleotide-based agents/ribozymes 130
    Other agents in development 131
  Drug Delivery Methodologies Used to Reverse P-gp MDR 132
    Aronex 132
  Combination of MDR Modulators in Cancer Therapy 132
  Monoclonal Antibodies 133
    Imgenex 133
Overcoming Other Types of MDR 133
  Overcoming Resistance to Topoisomerase II Poisons 133
  Overcoming Resistance to Free Radical-Mediated Drug Cytotoxicity 133
  Overcoming Resistance to Alkylating Agents and Platinum Compounds 133
    Terrapin Technologies 134
    Institute Pasteur 134
  Overcoming Resistance to Antimetabolites 134
    Sparta Pharmaceuticals 135
  Reversal of Apoptosis-Mediated Chemoresistance 136

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