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Volume 2, # 7/8 - November/December, 1996

Table of Contents

STATE-OF-THE-ART MANAGEMENT OF CANCER
BREAST CANCER­PART IV
Current Treatment Modalities
Breast Cancer Staging and Prognosis 410
Standard Treatment by Stage 410
  Carcinoma in situ 412
    DICS 412
    LCIS 414
  Stage I Breast Cancer 414
  Stage II Breast Cancer 415
    Postoperative chest wall radiotherapy 415
    Adjuvant combination chemotherapy 415
  Node-Negative Breast Cancer 419
  Stage IIIA (Operable) Breast Cancer 419
  Stage IIIB (Inoperable) Breast Cancer 419
  Stage IV Breast Cancer 420
  Inflammatory Breast Cancer 420
  Recurrent Breast Cancer 420
  Breast Tumor HIstology 420
  Staging by Hormonal Status 420
Surgery 420
  Standard Surgical Interventions 420
    Mastectomy 420
    Lumpectomy 423
  Novel Surgical Approaches 423
    Interstitial laser photocoagulation 423
    Cryosurgery 423
    Ultrasound 423
Radiation Therapy 423
Adjuvant, Neoadjuvant, Salvage and Palliative Treatment Approaches 424
Hormonal Therapy 425
  Antiestrogen Agents 425
    Tamoxifen 425
    Toremifine 426
  Aromatase Inhibitors 426
Standard Cytotoxic Chemotherapy 436
  Anthracyclines 436
  Taxanes 436
High-Dose (Density Chemotherapy (HDC) 437
  HDC with Hematopoietic Growth Factor Support 437
  HDC with Hematopoietic Cell Transplantation 438
    Autologous bone marrow transplant 439
    Peripheral blood stem cell transplantation 439
Treatment of Complications of Breast Cancer 440
  Hypercalcemia/Bone Pain Palliation 440
    Pamidronate 441
MEETING COVERAGE
MANAGEMENT OF BREAST CANCER
From the 19th Annual San Antonio Breast Cancer Symposium
San Antonio, TX - December 12-14, 1996
New Approaches in High Dose Chemotherapy For the Treatment of Breast Cancer 442
  High-Dose Chemotherapy with Stem Cell Support 442
  Tandem High-Dose Chemotherapy with Stem Cell Support 443
  Factors Predicting Survival with High-Dose Chemotherapy 443
  High-Dose Chemotherapy with Stem Cell Support in Non-metastatic Disease 444
  HER-2/neu Overexpression and Relapse 444
New Agents and Novel Regimens for Endocrine Therapy in Breast Cancer 445
  Estrogen Replacement Therapy 445
  Tamoxifen in the Neo-adjuvant Setting 445
  Aramatase Inhibitors 445
    Anastrozole 445
    Letrozole 445
    Liarozole fumarate 445
  Progesterone Receptor Antagonists 446
    Onapristone 446
  Combination Endocrine Therapies 446
    Interferon-?/i> 446
    Vinorelbine 447
  Re-evaluation of Stabilized Disease Associated with Endocrine Therapy 447
CORRECTIONS, ADDITIONS AND AMPLIFICATIONS
Corrections 447
  Introgen Therapeutics 447
Additions 447
  More on Prostate Cancer 447
    Bone Care International 447

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