FUTURE ONCOLOGY
Volume 3 # 7/8 November/December 1997
State-of the-Art in the Management of Cancer

Cancer of the Central Nervous System-Part I
Epidemiology, Etiology, Diagnosis and Prognosis

Worldwide Epidemiology of Primary CNS Tumors

USA Epidemiology

• Gender
• Race
• Age

Secondary CNS Tumors

Epidemiology of Metastatic CNS Cancer

• Neoplastic Meningitis

Etiology of Primary Tumors of the CNS

• Hereditary/Familial Factors
• Environmental Factors
• Viral Infections
• Other Factors

Molecular Genetics and Molecular Biology of Primary Brain Tumors

Gene Factors

• Chromosomal/gene abnormalities
• Gene amplification

Growth Factors

Diagnosis

• Neuroimaging
• Stereotactic Techniques
• In Vitro Tests
• Other Tests

Tumor Staging

Prognosis

Meeting Coverage

Cancer of the Central Nervous System

From the American Association of Cancer Research Conference

June 7-11, 1997, San Diego, CA

Targeting Regional Metastases of Brain Tumors

Targeting Protease Production

• Peptidyl methyl ketone
• Maramistat
• Carboxy-amido-triazole (CAI)

Mechanisms of Drug-Induced Apoptosis

Telomerase in Cancers of the Nervous System

Herpes Vectors for Brain Tumor Therapy

• Basic HSV Gene Therapy Vector
• Improved HSV Recombinant Vector
• HSV-1 Amplicon
• Helper Virus-free Packaging System

Farnesyltransferase Inhibitors and Anti-Ras Therapy

Targeting p53-Deficient Cells With Adenovirus Mutants

A Report on Molecular Medicine of Cancer, A Genetic Disease

from the Ninth Annual Usha Mahajani Symposium

at the Salk Institute, September 5, 1997

Methylation and Epigenetic Instability in the Development of Cancer

Imprinted Genes and Childhood Tumors

Methylation of Normal Genes

Hypermethylation

• Mismatch repair genes
• Epimutations
• Loss of a protective mechanism

Chromosomal Translocations in Cancer

Bcl-2

Genes Involved in the Pre-initiation of Cancer

Emerging Cytogenetic Technologies to Detect Quantitative Chromosome Changes

BRCA1 and BRCA2 Genes in Breast and Ovarian Cancer

• Mutations Vary by Geography
• Actionable Cancer-propensity Genes
• Sporadic Cancers
• Gene Therapy