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FUTURE ONCOLOGY
Volume 3 #9 January 1998
State-of the-Art in the Management of Cancer

Cancer of the Central Nervous System-Part II
Current Therapeutic Approaches

Surgery

  • Conventional Surgery
  • Stereotactic Radiosurgery

Radiotherapy

  • Conventional Radiation Therapy
  • Interstitial Radiation or Brachytherapy
  • International Isotopes

Boron Neutron Capture Therapy (BNCT)

  • Boron Biologicals

Radiosensitizers

  • Cisplatin or carboplatin
  • Etanidazole
  • Gadolinium texaphyrin (Gd-Tex)
  • Halogenated pyrimidine analogs
  • Sensamide and Neu-Sensamide
  • Tirapazamine

Hyperthermia

Photodynamic Therapy

  • Pacific Pharmaceuticals

Chemotherapy

Approved Drugs for CNS Cancer Indications

  • Carmustine and lomustine
  • Gliadel

Commercial Drugs in Clinical Trials for CNS Cancer Indications

Chemotherapy Delivery Options

  • Intra-arterial chemotherapy
  • Intrathecal chemotherapy
  • DepoCyt

Hematopoietic Support/Bone Marrow Transplantation

Current Treatment by Tumor Type

  • Primary Malignant CNS Cancer
  • Pediatric Tumors
  • Metastatic Brain Tumors and Cancer Metastasized to the Brain

Management of Treatment-Related and Other Complications

Hearing Loss

Peritumoral Brain Edema

  • Shunts
  • Steroids
  • Human corticotropin-releasing factor (hCRF)

Seizures

Meeting Coverage

NEW THERAPEUTIC APPROACHES IN NEURO-ONCOLOGY

From the 49th Annual Meeting of the American Academy of Neurology
Boston, MA, April 12-19, 1997

Gliomas

  • Interferon b -lA
  • Multimodality Regimens
  • High-dose Chemotherapy

CNS Lymphomas

Paraneoplastic Neurological Syndromes

  • Paraneoplastic Opsoclonus/Encephalopathy
  • Progressive Multifocal Leukoencephalopathy

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