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FUTURE ONCOLOGY
Volume 3 #10/11 February/March 1998
State-of the-Art in the Management of Cancer

Update of Prostate Cancer-PART I

EPIDEMIOLOGY
USA Epidemiology

Cancer of the Central Nervous System-Part III
Novel Therapeutic Approaches

Novel Chemotherapeutics

  • 9-aminocamptothecin
  • Alanosine
  • Diaziquone
  • Dibromodulcitol (DBD)
  • Fluorodeoxyuridine (FdUrd)
  • Hypericin
  • Mivobulin Isethionate
  • Phenylacetate
  • Phenylbutyrate
  • O(6)-benzylguanine
  • Rebeccamycin Analog
  • Suramin
  • Temozolomide
  • UCN-01

Receptor Targeting Strategies

  • CEP751
  • IL4 (38-37)-PE38KDEL
  • IL13-PE38QQR
  • SU101

Therapy Enhancement

Radiosensitization

  • RSR-13

Chemosensitization

  • Artificial oxygen carriers

Chemoprotection

  • Dexrazoxane

Novel Approaches to Prevent/Treat Metastases

Matrix Metalloproteinase (MMP) Inhibitors

  • Bryostatin-1
  • Marimastat

Inhibition of Angiogenesis

  • CAI
  • MAb 81C6
  • Thalidomide
  • TNP-470
  • Vascular endothelial growth factor

Selective Targeting of Tumor Vasculature

Exploiting Other Mechanisms

  • Brain-enriched hyaluronan-binding protein (BEHAB)
  • Ion channel

Immunotherapy/Vaccines

  • Antigen-specific (CD4+ and CD8+) T Lymphocytes
  • Activated Cytotoxic T Cells
  • Genetically-modified Tumor Cells
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF)

Anti-hCG Vaccines

Systemic Administration of Growth Factors/Cytokines

"Suicide" Gene Therapy

Adenoviral Vector-mediated Transfer

  • IntroGene
  • University of Pennsylvania

Parvoviral Vector-mediated Transfer

  • Avigen

Retroviral Vector-mediated Transfer

  • Chiron
  • Genetic Therapy/Novartis

Monoclonal Antibodies

  • Lexigen
  • Techniclone

Novel Potential Treatments Driven by New Gene Discoveries

Delivery of Therapeutics to the Brain

Electroporation for Delivery of Genes

Crossing the Blood-Brain Barrier (BBB)

  • Cereport
  • SP2000

Meeting Coverage

ADVANCES IN THE MANAGEMENT OF GASTROINTESTINAL CANCER
From the 62nd Annual Scientific Meeting of the American College of Gastroenterology (ACG)
Chicago, Illinois; November 3-5, 1997

Barrett's Esophagus

  • Prevalence of Short-Segment Barrett's Esophagus (SSBE)
  • Diagnosis and Treatment of SSBE

Prevention and Treatment of Esophageal Cancer

Photodynamic Therapy

  • Barrett's dysplasia
  • Refractory adenocarcinoma of the distal esophagus
  • Beta-carotene

Stents

Gastric Cancer

  • Neoadjuvant Chemotherapy

Colorectal Cancer

  • Benefits of Screening
  • Colon Cancer Prevention
  • Difluoromethylornithine (DFMO)
  • Aspirin
  • Argo

ADVANCES IN THE MANAGEMENT OF HEMATOLOGIC Malignancies
From the 39th Annual Meeting of the American Society of Hematology (ASH)
San Diego, CA; December 5-9, 1997

Acute Myelogenous Leukemia (AML)

  • Maxamine and IL-2 Combination Therapy
  • IL-2 Monotherapy

Acute Lymphoblastic Leukemia (ALL)

  • Shortened, Intensified Chemotherapy

Acute Promyelocytic Leukemia (APL)

  • Concurrent Induction Chemotherapy and All-trans Retinoic Acid (ATRA)

Chronic Lymphocytic Leukemia (CLL)

  • Cladribine

Chronic Myelogenous Leukemia (CML)

  • Decitabine

Myelodysplastic Syndrome (MDS)

  • Topotecan
  • Amifostine in Combination Therapy

Lymphomas

  • Poor Prognosis Malignant Lymphoma
  • Non-Hodgkin’s Lymphoma (NHL)

Treatment of Chemotherapy-Induced Side Effects

  • Thrombocytopenia
  • Mucositis
  • Recombinant keratinocyte growth factor

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