FUTURE ONCOLOGY
Volume 3 #10/11 February/March 1998
State-of the-Art in the Management of Cancer

Update of Prostate Cancer-PART I

EPIDEMIOLOGY
USA Epidemiology

Cancer of the Central Nervous System-Part III
Novel Therapeutic Approaches

Novel Chemotherapeutics

• 9-aminocamptothecin
• Alanosine
• Diaziquone
• Dibromodulcitol (DBD)
• Fluorodeoxyuridine (FdUrd)
• Hypericin
• Mivobulin Isethionate
• Phenylacetate
• Phenylbutyrate
• O(6)-benzylguanine
• Rebeccamycin Analog
• Suramin
• Temozolomide
• UCN-01

Receptor Targeting Strategies

• CEP751
• IL4 (38-37)-PE38KDEL
• IL13-PE38QQR
• SU101

Therapy Enhancement

Radiosensitization

• RSR-13

Chemosensitization

• Artificial oxygen carriers

Chemoprotection

• Dexrazoxane

Novel Approaches to Prevent/Treat Metastases

Matrix Metalloproteinase (MMP) Inhibitors

• Bryostatin-1
• Marimastat

Inhibition of Angiogenesis

• CAI
• MAb 81C6
• Thalidomide
• TNP-470
• Vascular endothelial growth factor

Selective Targeting of Tumor Vasculature

Exploiting Other Mechanisms

• Brain-enriched hyaluronan-binding protein (BEHAB)
• Ion channel

Immunotherapy/Vaccines

• Antigen-specific (CD4+ and CD8+) T Lymphocytes
• Activated Cytotoxic T Cells
• Genetically-modified Tumor Cells
• Granulocyte-macrophage colony-stimulating factor (GM-CSF)

Anti-hCG Vaccines

Systemic Administration of Growth Factors/Cytokines

"Suicide" Gene Therapy

Adenoviral Vector-mediated Transfer

• IntroGene
• University of Pennsylvania

Parvoviral Vector-mediated Transfer

• Avigen

Retroviral Vector-mediated Transfer

• Chiron
• Genetic Therapy/Novartis

Monoclonal Antibodies

• Lexigen
• Techniclone

Novel Potential Treatments Driven by New Gene Discoveries

Delivery of Therapeutics to the Brain

Electroporation for Delivery of Genes

Crossing the Blood-Brain Barrier (BBB)

• Cereport
• SP2000

Meeting Coverage

ADVANCES IN THE MANAGEMENT OF GASTROINTESTINAL CANCER
From the 62nd Annual Scientific Meeting of the American College of Gastroenterology (ACG)
Chicago, Illinois; November 3-5, 1997

Barrett's Esophagus

• Prevalence of Short-Segment Barrett's Esophagus (SSBE)
• Diagnosis and Treatment of SSBE

Prevention and Treatment of Esophageal Cancer

Photodynamic Therapy

• Barrett's dysplasia
• Refractory adenocarcinoma of the distal esophagus
• Beta-carotene

Stents

Gastric Cancer

• Neoadjuvant Chemotherapy

Colorectal Cancer

• Benefits of Screening
• Colon Cancer Prevention
• Difluoromethylornithine (DFMO)
• Aspirin
• Argo

ADVANCES IN THE MANAGEMENT OF HEMATOLOGIC Malignancies
From the 39th Annual Meeting of the American Society of Hematology (ASH)
San Diego, CA; December 5-9, 1997

Acute Myelogenous Leukemia (AML)

• Maxamine and IL-2 Combination Therapy
• IL-2 Monotherapy

Acute Lymphoblastic Leukemia (ALL)

• Shortened, Intensified Chemotherapy

Acute Promyelocytic Leukemia (APL)

• Concurrent Induction Chemotherapy and All-trans Retinoic Acid (ATRA)

Chronic Lymphocytic Leukemia (CLL)

• Cladribine

Chronic Myelogenous Leukemia (CML)

• Decitabine

Myelodysplastic Syndrome (MDS)

• Topotecan
• Amifostine in Combination Therapy

Lymphomas

• Poor Prognosis Malignant Lymphoma
• Non-Hodgkin’s Lymphoma (NHL)

Treatment of Chemotherapy-Induced Side Effects

• Thrombocytopenia
• Mucositis
• Recombinant keratinocyte growth factor