FUTURE ONCOLOGY
Volume 4 # 1/2 May/June 1998
State-of-the-Art in the Management of Cancer

Prostate Cancer-PART III
Current Treatment Modalities

Surgery Versus Brachytherapy

• Radical Prostatectomy
• Nerve-sparing (NS) prostatectomy

Radiotherapy/Brachytherapy

• Permanent interstitial implant brachytherapy
• High-dose-rate (HDR) temporary brachytherapy

Hormonal Therapy

Chemotherapy

• Estramustine
• Mitoxantrone
• Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)

Special Mid-year Review

Overview of Oncology Trends-PART I

New Chemotherapeutics Take-Off

Topoisomerase I Inhibitors

• Topotecan
• Irinotecan
• Other topo I inhibitors

Taxanes

• Paclitaxel
• Docetaxel
• Other taxanes/taxoids

Other Chemotherapeutics

• Mitoxantrone
• Gemcitabine

Newly Approved Chemotherapeutics, New Indications and Adjunct Therapies

• Anzemet
• Fareston
• Femara
• Intron A
• Neumega
• Neupogen
• Photofrin
• Proleukin
• Quadramet

New Chemotherapeutics Awaiting in the wings

• Capecitabine
• Denileukin diftitox
• Emitefur
• Oxaliplatin
• Raltitrexed
• UFT

Monoclonal Antibodies Come of Age

• Rituxan
• Herceptin
• Other HER2 MAb-based agents

Radioimmunoconjugates

Prevention/Treatment of Metastasis

Matrix Metalloproteinase Inhibitors (MMPI)

• Marimastat
• AG3340
• BAY 12-9566

Inhibition of Angiogenesis and Tumor Vascularization

• Thalidomide
• Endostatin and Angiostatin
• Squalamine

Chemoprevention

Antiestrogens in Breast Cancer

• Tamoxifen
• Raloxifene
• Other selective estrogen receptor modulators

Meeting Coverage

ADVANCES IN THE TREATMENT OF BREAST CANCER

From the 34th Annual meeting of the American Society of Clinical Oncology Los Angeles, CA; May 16-19, 1998

Antiestrogens in the Prevention of Recurrence of Early Breast Cancer

• Expression of c-erbB2 and Antiestrogen Therapy

Treatment of Locoregional Disease

• Use of Breast Conserving Therapy in the USA
• Economics of Locoregional Radiotherapy in Canada

Adjuvant Chemotherapy

• CAF versus CMF
• Capecitabine
• Paclitaxel

Treatment of Metastatic Breast Cancer

• Docetaxel
• Paclitaxel
• Vinorelbine and Paclitaxel Combination
• Losoxantrone
• High-dose Chemotherapy/Stem Cell Transplantation (HCSCT) Compared with Chemotherapy Alone
• Gemcitabine and Cisplatin Combination