FUTURE ONCOLOGY
Volume 4 #7/8 November/December 1998
State-of-the-Art in the Management of Cancer

Current Modalities used in the Treatment of Cervical Dysplasia, Carcinoma in situ (CIS) and Invasive Cervical Cancer (ICC)

Ablative Interventions

• Conization
• Loop electrosurgical excision procedure (LEEP)
• Cryotherapy
• Surgery

Radiation Therapy (RT)

• External beam irradiation
• Intracavitary brachytherapy
• Interstitial brachytherapy

Chemotherapy

• Radiosensitization
• Retinoids
• Apoptosis enhancement

Other Treatment Approaches

• Hyperthermia
• Photodynamic therapy

Current Treatment of Cervical Dysplasia and Cancer by Stage

Management of Low-grade Preinvasive Disease (CIN I or LSIL)

Treatment of High-grade Preinvasive Disease (CIN II/III, or HSIL, or CIS)

Treatment of Microinvasive Disease

Treatment of Early-stage Invasive Cervical Carcinoma (ICC)

Treatment of Advanced Cervical Cancer

Treatment of Disseminated Disease

Treatment of Recurrent Cervical Cancer

Prevention of HPV Infection

MediGene

MedImmune

Merck

New Approaches to Treat Precancerous Conditions/Cervical Dysplasia

Vaccines to Eradicate HPV Infection

• Cantab Pharmaceuticals
• Pangaea Pharmaceuticals
• University of Southern California

Chemoprevention

• b -carotene
• Curcumin
• Sulindac

Topical Treatment Approaches

• Interferon Science
• Matrix Pharmaceutical
• MAXIA Pharmaceuticals
• Pentose Pharmaceuticals

New Drugs in Development to Treat Cervical Cancer

Novel Chemotherapeutics

• Decitabine
• FMdC
• RPR 109881A
• Tirapazamine

Angiogenesis Inhibitors

• Ixsys
• Takeda

Ribozymes

Therapeutic Vaccines Against HPV

• Epimmune
• National Cancer Institute
• StressGen Biotechnologies
• Transgene
• University of Queensland

Other Immunotherapy Strategies

• Tumor-specific p53 or ras vaccines

Gene Transfer