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FUTURE ONCOLOGY
Volume 5 #1 May 1999
State-of-the-Art in the Management of Cancer

KIDNEY CANCER-PART IV
IMMUNOTHERAPY/TUMOR VACCINES

Adoptive Immunotherapy

Lymphokine-activated Killer (LAK) Cells

Tumor-infiltrating Lymphocytes (TILs)

Tumor-Sensitized Lymph Node Cells

Autolymphocyte Therapy (ALT)

Dendritic Cells (DC)

Active Specific Immunotherapy

Autologous Tumor Vaccines

Autologous Tumor-Derived Heat Shock Protein-Peptide Complex-96 (HSPPC-96) Vaccine

Tumor-Specific, Mutated, von Hippel-Lindau Peptides

CD40 Ligand (CD40L)

Anticancer Drugs and Markets

UPDATE ON TAXANES

Commercial Products

Taxol

Taxotere

Clinical Indications

Ovarian Cancer

Breast Cancer

Lung Cancer

Other Cancer Indications

The Outlook for Taxol and its Competition

Taxane Sources and Production Processes

  • Aphios
  • Cytoclonal Pharmaceutics
  • Dabur India
  • NaPro BioTherapeutics
  • Phytogen Life Sciences
  • Phyton
  • Samyang Genex
  • Xechem International

Generic Paclitaxel

  • Faulding
  • IVAX/Immunex
  • Mylan Pharmaceuticals
  • Sicor
  • SuperGen
  • Yew Tree Pharmaceuticals

Novel Formulations

  • Abbott Laboratories
  • Baker Norton Pharmaceuticals/Ivax
  • Cell Therapeutics
  • EnzyMed
  • Guilford Pharmaceutical
  • MacroMed
  • Matrix Pharmaceutical
  • NeoPharm
  • Phytogen Life Sciences
  • Pharmacia & Upjohn
  • Protarga
  • SuperGen
  • STS Particles/Medisperse
  • Xechem International

Novel Taxanes and Analogs

  • Aventis
  • Bristol-Myers Squibb
  • British Technology Group (BTG)
  • Indena
  • The Liposome Company (TLC)
  • Taxolog
  • Xechem International

Next Generation of Tubulin Stabilizing Drugs/Spindle Poisons

  • Apramycin
  • D-24851
  • Discodermolide
  • Eleutherobin
  • Epothilones
  • Halimide
  • LY355703
  • Laulimalide and isolaulimalide
  • T138067

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