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FUTURE ONCOLOGY
Volume 6 #12 June 15, 2002


Anticancer Drugs and Markets

UPDATE ON SPINDLE POISONS - PART II
VINCA ALKALOIDS AND ANALOGS/FORMULATIONS

Mechanism of Action of Vinca Alkaloids

Commercially Available Vinca Alkaloids

  • Vinblastine
  • Vincristine
  • Vindesine
  • Vinorelbine
    • Oral vinorelbine
Applications of Vinca Alkaloids in Development
  • Breast Cancer
  • Lung Cancer
  • Bladder Cancer
  • Other Cancers
Novel Vinca Alkaloid Analogs and Formulations
  • Anhydrovinblastine (AVLB)
  • Liposomal Formulations of Vinblastine and Vinorelbine
  • Vincristine Sulfate Liposome Injection (VSLI)
  • Vinflunine

Meeting Coverage

REFLECTIONS FROM THE MEETINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR),
APRIL 5-10, 2002, SAN FRANCISCO, CA
AND THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY (ASCO),
MAY 18-21, 2002, ORLANDO, FL

Novel Agents in Early-stage Clinical Development

Modulation of Signaling Pathways

Inhibition of Angiogenesis, Lymphoangiogenensis and Destruction of Existing Tumor Vasculature

Chemoprevention

Evidence-based Practice


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