• Topoisomerase I Inhibitors
  • DX-8951f
  • DE-310
  • LE-SN38
  • MBT-0312
  • Rubitecan
  • S-CKD602
• Antimitotics/Spindle Poisons/Cell-Cycle Modulators
• Cantuzumab mertansine
• CRx-026
• DHA-paclitaxel
• Disorazol E1
• DJ-927
• Flavopiridol
• MBT-0206
• Mebendazole (MZ)
• Antimetabolites/Nucleoside Analogs
• 4'-thio-FAC
• Clofarabine
• CYC682
• OSI-7836
• Tezacitabine
• Troxacitabine
• Antimetabolites/Thymidylate Synthase (TS) Inhibitors/Antifolates
• AG2037
• BGC 9331
• Davanat-1
• Nolatrexed dihydrochloride
• Pemetrexed sodium
• Alkylating Agents/Toxins
• Glufosfamide
• Ifosfamide
• Irofluven

OTHER NOVEL ANTICANCER AGENTS

• MPC-6827
• Natural Products/Vitamin Analogs
• Isoprenoids
• Perillyl alcohol
• SR271425
• Vitamin K₂
• Retinoids
• AGN193198
• SDX-102
• Triapine

DIGESTIVE ENZYMES

HORMONE MODULATORS

RADIOSENSITIZERS/CHEMOSENSITIZERS

• CoFactor
• Motexafin Ganolinium
• O(6)-benzylguanine

Exhibit 1 - Novel Cytotoxics, Hormone Modulators, Prodrugs/Formulations and Related Agents Evaluated Either Clinically or Preclinically for the Treatment of Pancreatic Cancer