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Future Oncology - Technology, Products, Markets, and Service Opportunities

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FUTURE ONCOLOGY - TECHNOLOGY, PRODUCTS, MARKETS, AND SERVICE OPPORTUNITIES IN THE CANCER FIELD

FUTURE ONCOLOGY
Volume 8 #1/2 October 2004


STATE-OF-THE-ART IN THE MANAGEMENT OF CANCER

PANCREATIC CANCER PART IV
NOVEL TARGETED THERAPEUTICS

CHALLENGES IN THE TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA (PDAC)
  • Heterogeneity
  • Resistance
  • Animal Models

TECHNOLOGIES EMPLOYED IN NOVEL TARGETED THERAPEUTICS IN PDAC

MAJOR MOLECULAR TARGETS/PATHWAYS IMPLICATED IN PDAC

  • Apoptosis Induction/Enhancement
    • AEG35156/GEM640
    • Imexon
    • Lestaurtinib
    • LY2181308
    • MPC-6827
    • RP101
  • Arachidonic Acid Pathway Ihibitors
    • Celecoxib
    • LY293111
  • Aurora Kinase Modulators
    • MP235
    • R763
    • VX-680
  • Epidermal Growth Factor Receptor (EGFr) Inhibitors
    • Cetuximab
    • EKB-569
    • Erlotinib
    • Gefitinib
    • Matuzumab
    • Panitumumab
  • Farnesyl Transferase Inhibitors (FTI)
    • Lonafarnib
    • Tipifarnib
  • Hedgehog Pathway Signaling Inhibitors
    • Cyclopamine
    • HhAntag
  • Mammalian Target of Rapamycin (mTOR) Signaling Pathway Modulators
    • AP23573
    • Everolimus
    • Temsirolimus
  • Mammalian Target of Rapamycin (mTOR) Signaling Pathway Modulators
    • AGRO1000
    • AP12009
    • ARRY-142886
    • ARQ 501
    • BMS-354825
    • Bortezomib
    • CC-401
    • GTI 2040
    • LY900003
    • PDO325901
    • Perifosine
    • RAV12
    • SDX-102


LIST OF EXHIBITS

Exhibit 1 - Novel Targeted Theraputics Evaluated Either Clinically or Preclinically for the Treatment of Pancreatic Cancer

Exhibit 2 - Selected Putative Targets of Novel Anticancer Agents in Development for Pancreatic Cancer

Exhibit 3 - Ongoing Randomized Combination Clinical Trials of Cetuximab in PDAC


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